BLOOMINGTON, Ind. -- Saquon Barkley scrapped for every yard through the first three quarters. For once, he looked ordinary.Penn State coach James Franklin decided to stick with the game plan, and eventually it paid off.Barkley ran for two go-ahead scores in the fourth, helping No. 12 Penn State beat Indiana 45-31 on Saturday.What you cant do when youre struggling in the run game is abort it, especially with a young offensive line, Franklin said. It was a gutsy, gutsy win on the road.Powered by a fantastic finish for Barkley, who was the Big Tens only 1,000-yard rusher at the beginning of the day. He had just 20 yards on his first 20 carries, but gained 40 in the final period to lead the Nittany Lions (8-2, 6-1, No. 10 CFP) to their sixth straight win.Barkley managed to have an impact even when he wasnt running with the ball.Barkleys first TD was set up by a 54-yard completion on a flea flicker when he served as the decoy, flipping the ball back to quarterback Trace McSorley. The Hoosiers (5-5, 3-4) bit hard on the play and a few moments later, Barkley walked in for a 4-yard TD run that lifted Penn State to a 28-24 lead.I thought our defense battled, Indiana coach Kevin Wilson said. Great job, great job on Barkley but because youve got a great back there, your guys have got to be on an island one-on-one.After Indiana regained the lead on Richard Lagows 40-yard touchdown pass to Nick Westbrook, Barkley ran over a defender for a 2-yard score with 3:58 left. Penn State sealed the victory with a 9-yard fumble return for a TD with 29 seconds to go.Barkley finished with 60 yards on 33 carries. McSorley was 16 of 30 for 332 yards with two TD passes and two interceptions.Indiana had won its previous two games. Lagow was 23 of 40 for 292 yards and two TDs, and Devine Redding ran 23 times for 108 yards and two scores.THE TAKEAWAYPenn State: The Nittany Lions maintained their long-shot division hopes, but still need help. They dropped their conference opener to the unbeaten Wolverines.Indiana: The Hoosiers blew a golden opportunity for a signature win. It would have been Indianas second Top 25 victory this season and secured bowl eligibility with two games to play. Next up is Michigan in Ann Arbor before finishing with rival Purdue in the regular-season finale.KEY NUMBERSIndiana lost five fumbles, four in the first half. Penn State made it 14-7 after recovering a muffed punt at Indianas 6-yard line. Penn State committed two turnovers, and the Hoosiers scored their second touchdown with one minute left in the first half after picking off McSorley.INJURY REPORTPenn States already depleted offensive line took another hit when left tackle Paris Palmer left in the first quarter with an undisclosed injury. Cornerback Jordan Smith was sent off by the refs after the first play of the fourth quarter to enter the concussion protocol.POLL IMPLICATIONSPenn State: The Nittany Lions could become the sixth Big Ten team to crack the top 10 this season.Indiana: The Hoosiers havent been ranked in the Top 25 since 1994 -- and this loss wont help them end the longest current drought for a power-five school.UP NEXTPenn State: Things should get easier next weekend when the Nittany Lions visit Rutgers, the last Big Ten team winless in conference play.Indiana: After playing four ranked teams in their last seven games, the Hoosiers face an even more daunting task next weekend. Michigan has won the last 20 in the series.---More AP college football: www.collegefootball.ap.org and https://twitter.com/AP-Top25Discount MLB Jerseys . 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President of baseball operations Larry Beinfest was fired Friday after 12 years with the Marlins. The move came as the team neared the end of its third consecutive last-place season in the NL East. SAN DIEGO (1-1) at INDIANAPOLIS (0-2)Sunday, 4:25 p.m. EDT, CBSOPENING LINE -- Colts by 3RECORD VS. SPREAD -- San Diego 2-0, Indianapolis 0-2SERIES RECORD -- Chargers lead 18-10LAST MEETING -- Chargers beat Colts 19-9, Oct. 14, 2013LAST WEEK -- Chargers beat Jaguars 38-14; Colts lost to Broncos 34-20AP PRO32 RANKING -- Chargers No. 20, Colts (tie) No. 27CHARGERS OFFENSE -- OVERALL (12), RUSH (3), PASS (25).CHARGERS DEFENSE -- OVERALL (23T), RUSH (7), PASS (29).COLTS OFFENSE -- OVERALL (18), RUSH (22), PASS (14).COLTS DEFENSE -- OVERALL (30), RUSH (29), PASS (25).STREAKS, STATS AND NOTES -- Chargers have won six of last seven in series, including three straight, and 12-3 all-time vs. Colts on road. ... San Diego opened season with back-to-back games of 150 yards rushing or more and will try to make it three in row for first time since final three games of 2006. ... Chargers defense looking to open season with three straight games with interception for first time since 2009 and trying to hold first three opponents to 83 yards rushing or fewer for first time since 1992. ... San Diego has allowed 10 total points through first three quarters last two weeks. ... After throwing four TD passes last week, QB Phillip Rivers needs four more to tie John Unitas (290) for No. 10 all-time. ... Rivers is expected to extend starts streak to 163, second in league behind Giants Eli Manning (185). ... RB Melvin Gordon trying to follow first career 100-yard game vs. NFLs fourth-worst run defense. ... Inside linebacker Manti Teo will return to Indiana for first time since playing college football at Notre Dame. ... WR Travis Benjamin is tied for fourth in AFC wiith 13 receptions.dddddddddddd ... Chargers defensive coordinator John Pagano and Colts head coach Chuck Pagano are brothers. ... Tom Telesco played key role with Colts before becoming Chargers GM, and recently signed receiver Griff Whalen spent first four seasons with Colts after being Andrew Lucks teammate at Stanford. ... Colts followed 0-2 start last year with three straight wins, and 0-2 start in 2014 with five straight wins. ... Indy last went 0-3 in 2011 and only other 0-3 start since Peyton Manning was drafted came in 1998, when 0-4 Colts beat Chargers for Mannings first NFL win. ... RB Frank Gore needs 101 yards to pass Hall of Famer Marcus Allen (12,243) for No. 12 on NFLs career list, 104 to pass Edgerrin James (12,246) for No. 11, and 137 to pass Hall of Famer Marshall Faulk (12,279) for No. 10, but Indy has gone 52 consecutive games without 100-yard rusher. ... Gore also needs one rushing TD to tie former Chargers RB Chuck Muncie (71) for No. 28 in league history. ... WR T.Y. Hilton needs seven catches for 300 and 11 receptions to pass Jimmy Orr (303) for No. 10 in franchise history. ... Colts will be without WR Donte Moncrief (fractured shoulder blade) for four to six weeks. ... K Adam Vinatieri has made 29 consecutive field goals. Fantasy Tip: Rivers has had some big games against Colts in past, and even if defense is healthier Sunday, they havent played together yet. Expect Rivers to take advantage of those problems and have big day.---AP NFL website: www.pro32.ap.org and http://twitter.com/AP-NFL ' ' '