. In this case, tissues withinside the adrenal glands themselves will become broken and inflamed, which alters how the adrenals produce hormones. Certain signs and symptoms of Addison’s ailment are basically the contrary of signs and symptoms of Cushing’s ailment, because they’re because of a deficit in cortisol in place of an extra. Addison’s signs and symptoms can consist of fatigue, weight loss, muscle wasting, temper swings and modifications to the pores and skin. Symptoms of adrenal fatigue may be comparable. Symptoms of High Cortisol Levels According to analyze completed through the Genetics Learning Science Center, the lengthy-time period threat of getting excessive cortisol is that it turns on the combat-or-flight reaction, which quickly shuts down regular reproductive, digestive and immune capabilities. The frame goals those structures for shutdown as it doesn’t want them for instant survival.